ATXN3 ELISA Kit for Human(Homo sapiens) | EIAab.comATXN3 ELISA Kit for Human(Homo sapiens)

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ATXN3 (Gene name),

Ataxin-3 (Protein name ), ATX3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ATXN3(ATX3;MJD;MJD1;SCA3);

Protein name:

Ataxin-3;

Alternative:

Spinocerebellar ataxia type 3 protein;Machado-Joseph disease protein 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with DNA repair proteins RAD23A and RAD23B.

Function:

Interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme.

Subcellular Location:

Nucleus matrix Predominantly nuclear, but not exclusively, inner nuclear matrix.

Protein Attributes:

Sequence length:

364

Sequence:

50:

100:

150:

200:

250:

300:

350:

364:

LHVIFALHYS | SFPL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

109150

SMR:

P54252

KEGG:

hsa:4287

UniGene:

Hs.532632

String:

P54252

Pfam:

PF02099

Uniprot:

P54252

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ELISA Kit for Human Ataxin-3

Cat.:

E10108h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Ataxin-3

Cat.:

E10108c

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Packing:

96T

ELISA Kit for Human Ataxin-3

Cat.:

E10108r

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96T

ELISA Kit for Human Ataxin-3

Cat.:

E10108m

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96T

CLIA Kit for Human Ataxin-3

Cat.:

U10108c

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MSDS:

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96T

CLIA Kit for Human Ataxin-3

Cat.:

U10108m

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96T

CLIA Kit for Human Ataxin-3

Cat.:

U10108h

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96T

CLIA Kit for Human Ataxin-3

Cat.:

U10108r

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96T

Polyclonal Antibody for Human Ataxin-3

Cat.:

P10108Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Ataxin-3

Cat.:

P10108Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Ataxin-3

Cat.:

P10108Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Ataxin-3

Monoclonal Antibody for Human Ataxin-3

Protein for Human Ataxin-3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1."
Kawaguchi Y. , Okamoto T. , Taniwaki M. , Aizawa M. , Inoue M. , Katayama S. , Kawakami H. , Nakamura S. , Nishimura M. , Akiguchi I. , Kimura J. , Narumiya S. , Kakizuka A.
Nat. Genet.8:221-228(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS MET-212; GLY-306 DELINS GLN-GLN-GLN-GLN-GLN-GLN-GLN-GLN-GLN-GLN-GLN-GLN-ARG AND 349-TYR--LEU-364 DEL;INVOLVEMENT IN SCA3
tissue: Brain.
2.

"Machado-Joseph disease gene products carrying different carboxyl termini."
Goto J. , Watanabe M. , Ichikawa Y. , Yee S.-B. , Ihara N. , Endo K. , Igarashi S. , Takiyama Y. , Gaspar C. , Maciel P. , Tsuji S. , Rouleau G.A. , Kanazawa I.
Neurosci. Res.28:373-377(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANTS MET-212; GLY-306 DELINS GLN-GLN-GLN-GLN-GLN-GLN-GLN-GLN-GLN-GLN-GLN-GLN-ARG AND 349-TYR--LEU-364 DEL
3.

"The genomic structure and expression of MJD, the Machado-Joseph disease gene."
Ichikawa Y. , Goto J. , Hattori M. , Toyoda A. , Ishii K. , Jeong S.-Y. , Hashida H. , Masuda N. , Ogata K. , Kasai F. , Hirai M. , Maciel P. , Rouleau G.A. , Sakaki Y. , Kanazawa I.
J. Hum. Genet.46:413-422(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3);VARIANT 349-TYR--LEU-364 DEL
4.

NIEHS SNPs program
Submitted (2007-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT MET-212
5.

"The DNA sequence and analysis of human chromosome 14."
Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT GLY-306 DELINS GLN-GLN-GLN-GLN-GLN-GLN-GLN-GLN-GLN-GLN-GLN-GLN-ARG
tissue: Mammary gland.
8.

"Ataxin-3 is transported into the nucleus and associates with the nuclear matrix."
Tait D. , Riccio M. , Sittler A. , Scherzinger E. , Santi S. , Ognibene A. , Maraldi N.M. , Lehrach H. , Wanker E.E.
Hum. Mol. Genet.7:991-997(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
9.

"Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities."
Li F. , Macfarlan T. , Pittman R.N. , Chakravarti D.
J. Biol. Chem.277:45004-45012(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes."
Tzvetkov N. , Breuer P.
Biol. Chem.388:973-978(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;FUNCTION
11.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosis."
Seki T. , Gong L. , Williams A.J. , Sakai N. , Todi S.V. , Paulson H.L.
J. Biol. Chem.288:17145-17155(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF CYS-14
13.

"The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates."
Scaglione K.M. , Basrur V. , Ashraf N.S. , Konen J.R. , Elenitoba-Johnson K.S. , Todi S.V. , Paulson H.L.
J. Biol. Chem.288:18784-18788(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT MET-1 AND LYS-200
14.

"Structural modeling of ataxin-3 reveals distant homology to adaptins."
Albrecht M. , Hoffmann D. , Evert B.O. , Schmitt I. , Wuellner U. , Lengauer T.
Proteins50:355-370(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING
15.

"The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition."
Nicastro G. , Menon R.P. , Masino L. , Knowles P.P. , McDonald N.Q. , Pastore A.
Proc. Natl. Acad. Sci. U.S.A.102:10493-10498(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-182
16.

"Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain."
Mao Y. , Senic-Matuglia F. , Di Fiore P.P. , Polo S. , Hodsdon M.E. , De Camilli P.
Proc. Natl. Acad. Sci. U.S.A.102:12700-12705(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-185;FUNCTION;MUTAGENESIS OF CYS-14; SER-236; SER-256 AND SER-335

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